Prof. Mauro Botta
Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale “Amedeo Avogadro” (Alessandria,Italy)
+39 3387970478 (cell) / +39 0131360253 (office)
We apply NMR relaxometry for the detailed investigation of the physico-chemical properties of complexes of trivalent lanthanide ions in order to obtain information about the changes that take place across the series, on the nature of the relaxation processes and their dependence on pH, and temperature, on self-recognition mechanisms, on the reversible formation of macromolecular adducts. These results are used for the design and development of effective metal-based (GdIII, MnII, FeIII) MRI contrast agents, both as low molecular weight complexes and as nanosystems in which multiple paramagnetic chelates are conjugated to scaffolds of different nature, size and complexity.