Prof. Carlos F.G.C. Geraldes
Department of Life Sciences, Faculty of Science and Technology, University of Coimbra (Coimbra, Portugal)
I have been working since the early 1970s in the field of NMR characterization of paramagnetic complexes including relaxometry measurements. I contributed to the relaxometric characterization the first Gd(III) based MRI contrast agents, which entered the clinical use, such as GdDOTA (DOTAREM), GdDTPA (MAGNEVIST) and Gd-DTPA-bis amides, as well as many other potential MRI CAs based on Gd(III), Ln(III), Mn(II/III) small complexes, as well as paramagnetic and superparamagnetic nanoparticles. I have used fast field cycling relaxometers since 1984 at the IBM Center with Seymour Koening, etc. analysing relaxometry profiles of a many systems. I contributed to the use of paramagnetic shifts and relaxation enhancements to the structural characterization in solution of small paramagnetic complexes and paramagnetically tagged proteins. My research interests include bioinorganic chemistry, paramagnetic NMR-based structural biology, NMR and EPR of paramagnetic species, relaxometry, MRI contrast agents, and NMR-based protein-ligand interactions.