Dr. Sławomir Wilczyński
Department of Basic Biomedical Science, School of Pharmacy, Medical University of Silesia in Katowice (Katowice, Poland)
+48 507 169 625
My researches are focused on three areas: (i) analysis of dosage forms, (i) investigations of the effect of active pharmaceutical ingredients on the skin and (iii) analysis of skin parameters relevant to pharmacotherapy. In my studies, I am using a wide range of non-invasive imaging techniques that enable to identify morphometric and spectroscopic parameters of drugs and tissues. These techniques and methods include: hyperspectral imaging, thermography, 3D scanning, microtomography, EPR spectroscopy, directional reflectance analysis. Important part of my research effort relates to the development of effective methods for identifying counterfeit drugs. Due to the fact that the above imaging methods used in the analysis of dosage forms generate data in a multi-dimensional (two or three-dimensional) space, they can be applied to the multimodal (understood as multicontext) differential analysis. This fact can be used in my studies on the identification of counterfeit drugs. Based on imaging methods and signal analysis, I propose counterfeit drug identification methods, which until now have never been applied. In my studies, the acquisition of image data has been supported by image analysis and processing methods, which allowed for their quantitative analysis. Thus, the results of these studies can be used for quantitative analysis of the effect of topically applied preparations on the tissue. The use of imaging methods also allows for the quantitative study of dosage forms, including the analysis of the distribution of the active pharmaceutical ingredient (API) and excipients with respect to the surface and / or volume of a dosage form. Distribution of the API and excipients in a dosage form is a critical parameter determining its efficacy and safety. Especially in this field - the impact of the excipients on API, I see a large possibility of application NMR relaxometry.